Construction of Three Dimensional Tissues of Osteosarcoma MG63 Cells Using a Rotating Wall Vessel Bioreactor and the Dose-Dependent Effect of Doxorubicin

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概要

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• Using a rotating wall vessel (RWV) bioreactor, which simulates a microgravity environment for cells, approximately 150 osteosarcoma MG63/collagen sponge composites (3 mmϕ x 3 mm) were three-dimensionally cultured simultaneously in a cylindrical vessel (250 ml) to produce the same number of cancer tissues of an equal size and quality. Then, these tissues were exposed to the anticancer drug doxorubicin, and dose dependence of the effect of this drug on the viability of the cells was examined compared with a conventional two-dimensional culture system. The dose-dependent effect on three-dimensional tissues was markedly different from the two-dimensional culture because of differences in the culture systems.

• ナノ・バイオメディカル学会の論文

著者

• UEMURA Toshimasa

  Nanosystem Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

関連論文

• Construction of Three Dimensional Tissues of Osteosarcoma MG63 Cells Using a Rotating Wall Vessel Bioreactor and the Dose-Dependent Effect of Doxorubicin
• PIV Analysis of Cartilage Regeneration Process from Bone Marrow Cells by Three Dimensional Culture using RWV Bioreactor

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