Adaptive criteria of microwave coagulo-necrotic therapy (MCN) for colorectal liver metastases

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Background: Techniques of microwave coagulo-necrotic therapy (MCN) for colorectal liver metastases (CRLM) have been revised in recent years. This retrospective study investigated the efficacy of MCN in the treatment of CRLM and determined the indications for MCN use in cases with CRLM.Materials and Methods: This study involved 243 patients with CRLM who underwent hepatic resection (HR) (n = 79),MCN (n = 111), or HR + MCN (n = 53) at our institution. Five-year survival was compared between the 3 groups of patients.Local control with MCN was assessed by investigation of local recurrence rates.Results: Overall 5-year survival rates of HR-, MCN-, and HR + MCN-treated cases were 45.9%, 40.0%, and 36.6%, respectively; the difference was not statistically significant. Furthermore, there was no significant difference in disease-free survival between the 3 procedures. Local recurrence was observed in 12 of the 111 MCN-treated cases. Tumor diameter >20 mm was identified as a significant predictor of increased local recurrence. MCN-related complications were associated with tumors >30 mm in diameter, irrespective of location.Conclusion: Tumor diameter ≤20 mm can be used as the adaptive criterion for MCN of deep hepatic lesions, whereas tumor diameter ≤30 mm should be the adaptive criterion for MCN of superficial lesions.
特定非営利活動法人 Microwave Surgery研究会の論文