Distribution of Activities of Collagen-Related Peptidases in Human Tissues

概要

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The distribution of three peptidases that may cleave collagen-derived peptides, PZ-peptidase (PZ-Pro-Leux Giy-Pro-D-Arg as substrate).SU-peptidase (Succinyl-Gly-Pro-Leu-Gly-Pro-4-methy-coumarinamide assub strate).and dipeptidyl-aminopeptidase I0V (DAP-IV-Giy-Pro-p-nitroanilide as substrate).were measured in human tissues.The activity of PZpeptidase was about 1/20 of that of SU-peptldase, but the activities of two enzymes were similarly distributed various tissues.whereas the activity of DAP-IV was predomlnant in kidney and submandibular gland and relatively high in the digestive system such as pan-Creas.liver, and small intestine.The activity of PZ-peptidase and that of SU-peptidase had weak correlation, but the activity of DAP-LV had no correlation with that of PZ-peptidase or SU-peptidase.The results indicate that PZ-peptidase and SU-peptidase may be similar enzymes and that DAP-IV may have different functions from those of PZ-peptidase and SUpeptidase. Since the correlation between PZ-peptidase and SU-peptidase was weak.clinical data obtained by SU-peptide should not be assumed to be identical with those obtained by PZ-peptide.
Japan Society of Clinical Chemistryの論文