Examination of an Inhibitory Effect on the Immunoglobulin E Production by Th2 Cytokine Inhibitor on Atopic Dermatitis
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概要
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We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups;<BR>(1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups.<BR>Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group.<BR>Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.
- 日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会 | 論文
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