A Successful Add-on Therapy of Hypereosinophilic Syndrome with Suplatast Tosilate

概要

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A Japanese woman in her forties complained of one-year history of episodic painful angioedema on her extremities associated with myalgia and dysesthesia. She also had a three-year history of bronchial asthma. Peripheral eosinophilia, and respiratory as well as cutaneous symptoms led to a diagnosis of hypereosinophilic syndrome. Her symptoms responded well to initial doses of oral corticosteroids but could not be maintained with low-doses of corticosteroids, experiencing relapses, often in the setting of corticosteroid tapering with an increasing eosiophil count. Suplatast tosilate was then commenced, added to oral corticosteroid, and led to a significantly reduced incidence of relapses with a decreasing eosinophil count. Suplatst tosilate can be a useful add-on therapy in patients who experience relapses.
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文