A Case of Systemic Plasmacytosis Improved by the Treatment with Mizoribine

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A 53-years-old man presented with asymptomatic brownish plaques of the trunk since 7 years before. He was suffering from lasting fever, lymphadenopathy, nausea, diarrhea and dizziness. A skin biopsy showed nodular infiltrates of plasma cells in the dermis. A lymph node biopsy revealed marked plasma cells beneath the capsule. Laboratory examinations indicated polyclonal hypergammaglobulinemia, whereas C-reactive protein was elevated slightly and IL-6 was 3.4pg/ml. The diagnosis of systemic plasmacytosis was made. Although the treatment with betamethasone 6mg/day was not sufficient, these symptoms were improved after the addition of mizoribine 300mg/day.Skin Research, 11: 173-178, 2012
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文