A Case of Acute Generalized Exanthematous Pustulosis Induced by Nonionic Iodocontrast Media, Iohexol

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A 76-year-old man presented with systemic erythema and high fever. Ten hours before the onset of the symptom, he was examined by cystography computed tomography using the nonionic iodocontrast media, iohexol because of the pancreatic cyst. Two days later, he developed small pustules on his back, abdomen and axilla. Histopathology of a biopsy specimen taken from a back showed subcorneal pustules. According to the skin test and drug-induced lymphocyte stimulation test (DLST), he was diagnosed as acute generalized exanthematous pustulosis (AGEP) induced by iohexol. AGEP induced by nonionic iodocontrast media was rare, but we need to recognize nonionic iodocontrast media is one of the cause of AGEP. And in our case, there is a possibility that preceding upper respiratory infection and anti-SSA antibody were with positive did some kind of contribution for the onset of the AGEP.Skin Research, 11: 165-169, 2012
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文