Comparison of Skin Barrier Function and Sensory Nerve Electric Current Perception Threshold between IgE-High Extrinsic and IgE-Normal Intrinsic Types of Atopic Dermatitis
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Two types of atopic dermatitis (AD) have been proposed with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgE levels presumably as a consequence of skin barrier damage and feasible allergen permeation, whereas the intrinsic type exhibits normal IgE levels and is not mediated by allergen-specific IgE. To investigate the relationship between pruritus perception threshold and skin barrier function of AD patients in a comparison between the extrinsic and intrinsic types. The skin surface hydration was significantly lower and the transepidermal water loss (TEWL) was significantly higher in extrinsic AD than intrinsic AD or normal control. Although there was no statistically significant difference in the electric current perception threshold (CPT) among extrinsic AD, intrinsic AD, and normal control, CPT was significantly correlated with skin surface hydration and inversely with TEWL in intrinsic AD and normal control, but not extrinsic AD. Finally, CPT was correlated with the visual analogue scale of itch in the lesional skin of the extrinsic but not intrinsic AD patients. The extrinsic AD patients have the impaired barrier, which increases the preexisting pruritus but rather decreases the sensitivity to the external stimuli. In contrast, the intrinsic AD patients retain the normal barrier function and sensory reactivity to external pruritic stimuli.Skin Research, Suppl. 16: 11-14, 2011
- 日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会の論文
日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会 | 論文
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