Development of tissue conditioner capable of binding with anti-microbial protein lactoferrin

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概要

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• Purpose: This study focused on the anti-microbial protein human lactoferrin (hLF) commonly found in saliva, and tried to develop biocompatible dental materials that have higher anti-microbial effects. <BR>Methods: A lyophilized cation exchange resin was added to tissue conditioner at 4 wt% and 8 wt%. The amount of hLF binding to the tissue conditioner and their anti-microbial effect against Candida albicans was investigated. Then their mechanical properties and cytotoxicity were examined. <BR>Results: Tissue conditioner containing cation exchange resin was bound with hLF and had an anti-microbial effect against C. albicans. In addition, their physical properties were sufficient and they were harmless to human fibroblasts. <BR>Conclusion: The clinical application of cation exchange resin for tissue conditioner can be effective for the prevention and treatment of denture stomatitis and systemic opportunistic infections since it is thought that these materials will increase the local concentration of anti-microbial protein in saliva at the lesion site.

• 社団法人 日本補綴歯科学会の論文

著者

• Yamamoto Daigo

  Section Of Fixed Prosthodontics Division Of Oral Rehabilitation Faculty Of Dental Science Kyushu Uni

• Terada Yoshihiro

  Section Of Fixed Prosthodontics Division Of Oral Rehabilitation Faculty Of Dental Science Kyushu Uni

• Nagadome Hatsumi

  Section Of Fixed Prosthodontics Division Of Oral Rehabilitation Faculty Of Dental Science Kyushu Uni

• Shinohara Yoshinori

  Section Of Fixed Prosthodontics Division Of Oral Rehabilitation Faculty Of Dental Science Kyushu Uni

• Nagadome Hatsumi

  Section of Fixed Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science

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• Development of tissue conditioner capable of binding with anti-microbial protein lactoferrin
• Application of Anti-Microbial Protein Lysozyme for Dental Materials
• Antimicrobial and antifungal effects of tissue conditioners containing a photocatalyst
• The usefulness of three-dimensional imaging for prognostication in cases of intentional tooth replantation
• The usefulness of an autologous blood clot combined with gelatin for regeneration of periodontal tissue
• Development of tissue conditioner capable of binding with anti-microbial protein lactoferrin

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