Causes and Differential Diagnosis of Hypocalcemia -Recommendation Proposed by Expert Panel Supported by Ministry of Health, Labour and Welfare, Japan-

スポンサーリンク

概要

• 論文の詳細を見る

• Serum calcium (Ca) level is maintained within a narrow range mainly by actions of parathyroid hormone (PTH) and 1,25-dihydroxyvitmain D [1,25(OH)2D]. While it is not rare to encounter hypocalcemia in clinical practice, there is currently no practical guideline for the differential diagnosis of hypocalcemia. We therefore propose flowcharts for the differential diagnosis of hypocalcemia and hypoparathyroidism, especially PTH-deficient hypoparathyroidism in which many genetic or other causes have been identified recently. Hypocalcemia can be divided into two categories, hypocalcemia with low serum phosphate level, and one with normal to elevated serum phosphate level. Deficient actions of 1,25(OH)2D, loss of Ca into urine, and deposition of Ca in bone or soft tissues are main causes of hypocalcemia with low to low normal serum phosphate level. Hypocalcemia with high normal to high serum phosphate level includes chronic renal failure and hypoparathyroidism. Hypoparathyroidism is subdivided into PTH-deficient hypoparathyroidism and pseudohypoparathyroidism. Recent investigations identified several causes of PTH-deficient hypoparathyroidism, including genetic abnormalities and parathyroid autoantibodies, which should be differentiated from idiopathic hypoparathyroidism. Physical and laboratory findings, the time of the onset of diseases and accompanying illness can be clues for identifying causes of PTH-deficient hypoparathyroidism.

• 一般社団法人 日本内分泌学会の論文

一般社団法人 日本内分泌学会 | 論文

• 性ホルモンと生体反応
• A Hexapeptide Angiotensin Antagonist, [Des-(Asp1, Arg2), Ile8]-Angiotensin II
• 甲状腺ホルモンの吸収に関する研究
• DISC ELECTROPHORETIC ANALYSIS OF GROWTH HORMONE AND PROLACTIN IN THE ANTERIOR PITUITARY OF MOUSE
• 機能性甲状腺結節 (Autonomous Functioning Thyroid Nodule) 及び周辺組織におけるヨード代謝

もっと見る

スポンサーリンク