Histopathology of the basal layer of cholesteatoma's epithelium.

概要

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The epithelium of surgically removed cholesteatoma (27 cases) was observed microscopically in order to investigate the mechanism how keratin enter into the sub-epithelial connective tissue.<BR>3 kinds of findings suggested the rupture of the basement membrane, that is, (1) rupture of all the epithelial layer (2 cases), (2) accumulation and invasion of mononuclear like cells to rete malpighii (19 cases), and (3) acanthosis with elongation of rete ridge associated with irregular forming of the basal layer.<BR>Considering the fact that frequently observing the kerarin granuloma in bone destructive cholesteatoma, the latter two findings seemed to relate with the release of keratin into the subepithelial layer.
日本耳科学会の論文