Changes in EP during nifedipine perilymphatic perfusion.
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概要
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A calcium channel blocker, nifedipine was applied to cochlea by perilymphatic perfusion. EP decreased gradually after perfusion wiht the nifedipine solutions when the concentration was higher 100ng/ml. At a concentration of 200ng/ml, EP decreased from+70mV to 14mV. At 1000ng/ml, it decreased from+70mV to +54mV and stayed at this level during perfusion. From these results, it is considered that calcium influx to stria vascularis plays a role in maintaining EP. There are three possible explanations for the influence of nifedipine on EP. The most likely explanation for the decrease in EP is that through Na-Ca exchanges, a fall in the intracellular Na concentration inhibits the Na-K pump or K pump. The second explanation is related to cAMP and the third involves diffusion potential.
- 日本耳科学会の論文
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