Comparison of ototoxicity among four kinds of anticancer platinum drugs.
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Four kinds of anticancer platinum drugs (Cisplatin, Carboplatin, 254-S and DWA2114R) were administrated to the guinea pigs intraperitoneally. Ototoxicities of these four drugs were investigated electrophysiologically and morphologically. The group of Cisplatin was divided into three groups of 5mg/kg for 3 consecutive days, 5mg/kg for 2 consecutive days and 1mg/kg for 5 consecutive days. The ratio of doses per each administration of these drugs was 1 (Cisplatin) to 3 (254-S) to 10 (Carboplatin and DWA2114R), which are based on LD<SUB>50</SUB>. From the result of N<SUB>1</SUB>, threshold of action potential, ototoxicity of DWA2114R was milder than the other three drugs. And from the survived outer hair cell numbers (%) counted by scanning electron microscopy, ototoxicities of Cisplatin and 254-S were stronger than those of Carboplatin and DWA2114R.
- 日本耳科学会の論文
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