The observation on the correlation between the chlorine ion concentration of endolymph and EP under various conditions.

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The Cl--concentration in endolymph (Cl--endo) and the EP were recorded simultaneously from the basal turn of the cochlea of guinea-pigs with a double-barreled Cl--electrode during anoxia and after furosemide or glycerol injection. From the experimental results, the following conception could possibily be suggested: (1) The permeability of Cl- between endolymph and perilymph is less than that of K+ and Na+. (2) There is no necessity for assuming the existense of Cl--pump which draws out Cl- to the stria from endolymph and participates in generation for EP. (3) The stability of Cl--endo in various conditions must be due to the solvent traction. (4) At the condition of too much rapid dehydration in endolymph which induced by such as glycerol injection, the movement of Cl- does not always follow to the rapid water movement resulting in the slight increase of Cl--endo.
日本耳科学会の論文