Identification of platelet-activating factor(PAF) in middle ear fluids from OME.
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概要
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Platelet-activating factor, a biologically active ether lipid, has been suggested as an important mediator in inflammation. In order to characterize the biochemical features of OME, we have examined the PAF activity using 17 middle ear fluids. In 7 ears, we detected the PAF activity, which was characterized by the behavior on thin layer chromatography and by the treatment of CV-3988, a specific antagonist to PAF molecule.<BR>From the above, there are cases that PAF presents in middle ear fluids from OME, and it may suggest that PAF play an important role in the pathogenesis of OME.
- 日本耳科学会の論文
日本耳科学会 | 論文
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