Suppressive effect of the calcium antagonist on spontaneous discharge in the cochlear nucleus neurons.

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The effect of calcium antagonist on asphyxia induced spontaneous discharges was examined. As the experimental animal young adult cats which were anestetized with pentobarbital (40 mg/kg), petazocine and diazepam were used. Characteristic frequency, threshold and spontaneous discharge rate of the auditory neuron in the cochlear nucleus was obtained before, during and after asphyxia. As a calcium antagonist diltiazem was selected and injected into the femoral vein. Change of spontaneous discharges, EEG and ECG were obtained and concentration in the blood of diltiazem was also measured. After administration of diltiazem spontaneous discharges were proportionaly decreased in grade of amount of injection from slight to complete. From the present observation the following results were obtained that asphyxia induced spontaneous discharges of the auditory neurons in the cochlear nucleus were suppressed by calcium antagonist and dose related effect was predictable.
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