Altering ATPase activity between guinea pigs' sensory hair cells and afferent nerve endings during the experimentally induced vertiginous attack

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The "Rupture theory" of Schuknecht (1963), has been proposed to explain the vertiginous attack of Meniere's disease, and the high perilymphatic potassium ion was thought to be the most important factor in this theory. In this paper, potassium ion was introduced through the round window into the perilymphatic space of guinea pig by means of iontophoresis to histochemically investigate the effect of high perilymphatic potassium concentration on the sensory epithelia in the labyrinth. After the iontophoretic procedure, spontaneous nystagmus was observed. Nystagmus directed toward the iontophoretic side (irritative nystagmus) for the first 10 minutes, and then toward the unaffected side (paralytic nystagmus) for later 24 hours. These nystagmus were quite reversible and left no morphological change of sensory cells. But, histochemical analysis revealed the increased ATPase activity during the irritative nystagmus and the decreased ATPase activity during the paralytic nystagmus in the synaptic area between the hair cells and the nerve endings of the iontophoretic side. According to these results, high perilymphatic potassium concentration was supposed to affect the synaptic area of sensory epithelia and was able to produce reversible nystagmus.
日本耳科学会の論文