Experimental study on the K+-concentration in the strial cells of guinea-pigs.

概要

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The series of this study was undertaken to clarify the distribution of K+-concentration in the stria vascularis (SV) with relation to that of DC potential. In this experiment, the effect of anoxia on the DC potential and the K+-concentration in the strial cells (SC) was investigated simultaneously by inserting a double-barrelled K+-sensitive microelectrode into the SV of guinea-pig cochlea. In the marginal cell (MC), the rapid and marked reduction of both the intracellular K+-concentration (K+-in) and the intracellular DC potential (DC) could be always observed by anoxia, while the K+-concentration in endolymph did not show any appreciable change during anoxia. In the intermediate cell (IC), K+-in increased slightly by anoxia in contrast with the decline of DC. The reduction of K+-in in MC should be originated in the stop of the K+-pump action which draw in K+to cell inside and in the passive transport for K+to cell outside. As the reason for the slight increase of K+-in in IC, it might probably be assumed that the permeation for K+ caused by passive transport at this cell membrane takes place to the cell inside because of the lower K+-in than that of the other SC. The above data might be expected to suggest the localization of K+-pump and the movement for K+in the SC layers.
日本耳科学会の論文