Effects of intravenous injection of Lidocaine on the cochlear nerve action potentials.

概要

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Our previous report showed that injection of Lidocaine reduced the spontaneous discharge rate of the cochlear nerve transiently. But the action sites of Lidocaine is not yet clear. To know the effects on the nerve, we recorded the latencies and the thresholds of the cochlear nerve action potentials (spikes) which were evoked by the electrical pulses applied through the round window membrane before and after intravenous injection of Lidocaine. According to Moxon (1971), The electrical pulses excite the unmyelinated nerve directly. Threshold at one min after injection of Lidocaine was about two times of that of preinjection and decreased linearly. It takes 36 min for the nerve to return to the level of preinjection. The mean onset of decrease of of the latencies of the spikes is about 36 sec after onset of injection (n=12). This reveals that intravenous injection of Lidocaine acts directly on the cochlear nerve and decreases the excitability of the nerve transiently.
日本耳科学会の論文