Auditory Brain Stem Response in Neuropathological Mutant Mice (Shiverer and Reeler)

概要

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Auditory brain stem response (ABR) was investigated on Shivere mice and Reeler mice.<BR>In the case of Shivere mice, it was observed that the latency was prolonged in waves after ABR Wave II and the disappearance of Wave V was also observed. Although the interpeak latency was also prolonged, there were some differences accoding to the region. The threshold was found normal.<BR>On the other hand, in the case of Reeler mice, findings diversified with respect to the waveshape and latency since some did not show any difference as compared to the control, some showed a prolonged latency and in some cases the only wave that was recognized was Wave I.<BR>The findings on ABR of the Shivere mice were considered due to the absence of myelin formation. In view of the findings on ABR of the Reeler mice, it was presumed that the brain stem disorder would probably be a secondary change rather than a primary change.
日本耳科学会の論文