Cisplatin Ototoxicity
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概要
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Electrophysiologic and histopathologic changes in the cochlea following administration of cisplatin were studied in guinea pigs. Hearing function was tested by ABR and morphological studies were conducted by scanning electron microscope. The susceptibility to cochlea by cisplatin was dose-dependent. A recovery was observed in ABR in some animals which were given 9mg/kg cisplatin intramuscularly. The outer hair cells were mainly damaged in the basal and second turns. The first and the second rows of them tended to be more severely damaged. The inner hair cells were rarely damaged. There was a close correlation between loss of cochlear hair cells and suppression of ABR. However, mild cochlear damage was observed in some guinea pigs, which represented no hearing impairment.
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