Evaluation of Ototoxicity of Aminoglycoside Antibiotics injected into the Facial Nerve through the Stylomastoid Foramen of Rabbit (Second Report)

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The ototoxicity of various aminoglycoside antibiotics, tobramycin (TOB), gentamicin (GM), kanamycin (KM), amikacin (AMK), and dibekacin (DKB), was evaluated after a single injection into the facial nerve through the stylomastoid foramen. Sixty-nine albino rabbits weighing about 3kg were used. Each drug was dissolved 100mg/ml, and 0.04ml given. The concentration of these drugs in perilymph and tympanic cavity was concurrently measured. No hair cell damage was observable in any rabbit decapitated 24hours after the injection. But in all animals decapitated 10 days after the injection, outer hair cells were damaged. The outer hair cell damage caused by TOB and GM was far higher than that from KM, AMK or DKB. However, there were no differences in the perilymph concentration among these drugs. These results coincide with the ototoxic evaluation of these drugs when given by general administration. Mechanism of inner ear damage caused by an injection of aminoglycoside antibiotics into the facial nerve through the stylomastoid foramen is discussed.
日本耳科学会の論文