Effects of Adenosine triphosphate on the Vascular System of the Inner Ear

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Changes in vertebral and common carotid arterial blood flow caused by intraveous administration of adenosine triphosphate (ATP), betahistine, papaverine, diphenidol were examined in anesthetized dogs. The increase of blood flow caused by ATP was appeared dose-dependently from dose of 1 μg/kg. The potency of this effects were followed: Betahistine>ATP, papaverine>diphenidol. Then, the effects of intraduodenally administered ATP on the vascular system of the inner ear were examined in guinea pigs. The increase in the diameter of the blood vessels was observed in cochlear and vestibular system. The effects began to appear at dose of 100 mg/kg and became maximum at dose of 500mg/kg. The effects were most prominent 15 minutes after administration and became decreased gradually to normal value 90 minutes later.
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