Experimental Otitis Media with Effusion (Carrageenins Induced)

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Otitis media was induced in guinea pigs by intrabullar injection of 1% Carrageenins. The animals were sacrificed for histological examinations at 1 to 14 days respectively. The gross appearance of bulla was most hyperemic and thickened mucosa reaction on 3 or 4 days. Effusion was most abundant on 3 or 4 days. Each specimens are examined under light and electron microscopes. At 24 hours, the subepithelial layer was edematous, and epithelial cells contained electron dense granules. On 3 days, epithelial and subepithelial layer were most remarkably edematous, and macrophages, neutrophils and mast cells were seen in the mucosa. The macrophages contained many electron dense granules and dispersed lysosomes. Some of them were present adjacent to the capillaries, which permeability appeared to be enhanced. The mast cells granules showed less electron density and some of them fused with each other. On 7 or 14 days, the edema had disappeared and infiltration cells were not numerous.
日本耳科学会の論文