Neurotransmitters from Inferior Olive to Lateral Vestibular Nucleus

概要

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The study was performed to elucidate the effect of inferior olive (I0) stimulation on the lateral vestibular nucleus (LVN) neurons monosynaptically activated by vestibular nerve stimulation using decerebellated cats. Furthermore, possible neurotransmitters involved in the transmission from IO to LVN were studied. Forty-three out of 160 LVN neurons were monosynaptically activated by IO stimulation and the excitatory response was blocked by iontophoretic application of atropine. An inhibition by IO conditioning stimulation of orthodromic spikes with vestibular nerve stimulation was observed in 22 LVN neurons, and the inhibition was antagonized by iontophoretic application of bicuculline, a GABA antagonist. HRP study showed existence of fiber connection from the dorsal cap and β nucleus of IO to the LVN. These results suggest that the LVN neurons monosynaptically activated by vestibular nerve stimulation receive both excitatory and inhibitory inputs from the contralateral IO and neurotransmitters involved in the excitatory and inhibitory transmission are acetylcholine and GABA, respectively.
日本耳科学会の論文