Effects of isosorbide on the perilymphatic pressure and oxygen tension in cats

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The effectiveness of isosorbide, the dianhydrate of sorbitol, in lowering the perilymphatic pressure and elevating the perilymphatic oxygen tension was shown in ten fasting cats. The cochlear aqueduct of the cat was obliterated two to four weeks proir to the measurements. The perilymphatic pressure was measured using servo-controlled micropipet system. The oxygen tension was measured using polarographic technique. Both the effects of the intravenous and oral administration were tested. By the intravenous administration (2g/kg), the perilymphatic pressure has shown 158% drop in 24 minutes. Strong rebound phenomenon (135% rise to the initial value), However, was noted in 150 minutes. On the contrally, there noticed was no rebound phenomenon in oral administration where 60% drop was monitored in 50 minutes. Perilymphatic oxygen tension was elevated up to 246% of the initial value in 13 minutes by the intravenous administration of isosorbide.
日本耳科学会の論文