Effect of anaesthetic agents on auditory brainstem response

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The effect of anaesthetic agents on the auditory brainstem response (ABR) was studied in 34 patients with 68 ears. Twenty-four cases received NLA anaesthesia and 10 cases received GOE anaesthesia. After the induction with thiopental and succinylcholinchrolide, anaesthesia was maintained with 66% nitrous oxide in oxygen. The cases with NLA anesthesia were divided into three groups as follows according to anesthetic agents. A: Droperidol and fentanyl (7 patients, 14 ears) B: Diazepam and pentazocine (7 patients, 14 ears) C: Droperidol and pentazocine (10 patients, 20 ears) Ten cases, 20 ears anaesthetized with 1.5% concentration enflurane were classified as group D. ABRs were recorded 30 minutes after intubation, and latencies of waves I, III, V and interpeak latencies of waves I-III, III-V, and I-V were analysed. The results showed that under NLA method there was no significant prolongation of latencies of ABR waves except absolute latency of wave I. However, in the cases anaesthetized with 1.5% enflurane, latency of wave V and interpeak latencies of waves I-V and III-V showed significant increases. The results suggested that enflurane delays neural transmission of auditory pathway in the upper brainstem.
日本耳科学会の論文