A CASE OF PRIMARY MALIGNANT MELANOMA OF THE VAGINA

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Background: We report a rare case of malignant melanoma of the vagina diagnosed by cytology and bioptic histopathology with immunohistochemical techniques.Case: A 69-year-old woman was admitted with a chief compliant of genital bleeding. A polypoid lesion was found in the lateral vaginal wall, and cytology and biopsy were performed. Cytology revealed large, round or oval nuclei, possessing characteristic basophilic nucleoli and melanin pigments in varying amounts from cell to cell. Cytological findings were suggestive of malignant melanoma. Upon histological examination, these pigments were positive for Fontana-Masson staining. The histopathological diagnosis, considering that the tumor cells were positive for S-100 and HMB45, but negative for keratin, EMA and LCA upon immunohistochemical examination, was malignant melanoma.Conclusion: Malignant melanoma originating primarily from the vagina is a very rare tumor. The characteristic cytological findings of the tumor cells were helpful in establishing a diagnosis.
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