DRUG TREATMENT IN THE ELDERLY OPENING COMMENTS BY THE MODERATOR
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概要
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Rapid aging of the population has led to a dramatic increase in elderly patients seeking treatment at medical institutions. Degeneration in organ function and loss of reserve capacity are not simply physiological corollaries of aging. These conditions are frequently exacerbated by other pathological changes. When administering drugs to the elderly, it is vital to consider not just the pharmacokinetic aspects but also the pharmacodynamicsabsorption and distribution throughout the body, metabolism and excretion. It has been said that when prescribing drugs for the elderly, as opposed to younger patients, not only must we exercise greater caution in determining drug choice and amount, metabolic dynamics and side effects, but we must also give detailed guidance about the proper use, so patients understand the necessity and consequences of the drug in terms of overall treatment. Patients can thus receive a minimum dosage and take it faithfully as directed.Some characteristics of elderly patients: (1) They are more liable to develop high serum drug concentrations because of excretory limitations imposed by the slowdown in metabolic function, especially in the kidneys and liver. (2) Decline in serum albumin levels aggravates any rise in free serum drug content. (3) Patients often receive treatment for a number of ailments at several unrelated hospitals, meaning they may be taking many types of medication at once. (4) Because many ailments in the elderly are chronic, drug treatment continues over extended periods, creating a higher risk for side effects. (5) Difficulty in making the patients understand often leads to poor compliance.Various approaches to these problems are now being studied. In view of recent trends, we have invited presentations on a wide range of topics related to medication use in elderly patients.
- 一般社団法人 国立医療学会の論文
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