Diagnostic significance of cea measurement in the management of patients with abnormal nipple discharge.

概要

論文の詳細を見る
CEA levels in nipple discharge were measured in eighteen patients with bloody nipple discharge, by dot-immunobinding assay using monoclonal antibody. The results were as follows.1) Six out of eight patients with breast cancer had higher CEA levels than cutoff value (200ng/ml). On the other hand, CEA levels of six benign lesions (5 intraductal papilloma, 1 fibrocystic disease) were lower than cutoff value.2) Sensitivity and specificity of this examination was calculated to be 75%, 100% respectively. High accuracy rate of 85.7%, therefore, was obtained.3) CEA levels in nipple discharge were compared with cytological findings. As a result, we confirmed that either elevated CEA levels or positive cytology strongly suggested the presence of cancer.4) In addition, the characteristics of patients with breast cancer discovered with CEA measurement were listed. It was noteworthy that four out of eight cases were non-invasive Cancers.These results suggest the importance of application of CEA measurement in nipple discharge into the screening method of non-palpable breast cancer.
一般社団法人国立医療学会の論文