Serum and urine myoglobin level in children with chronic renal diseases.

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We measured serum and urine myoglobin (Mb) in children with various stages of chronic renal diseases. Furthermore, we investigated the correlation between Mb andbeta 2-microglobulin (β2-M), blood urea nitrogen (BUN) or creatinine (Cr) and the following results were obtained.1) Serum Mb in normal children was 24.6±15.0 ng/ml. In patients with nephrotic syndrome or membranous proliferative glomerulonephritis and with normal renal function, serum Mb was within normal limits. In 2 patients with chronic glomerulonephritis and with disturbed renal function, serum Mb level was significantly high.In IgA nephropathy, other persistent glomerulonephritis and Henoch-Schönlein purpura nephritis, serum Mb was within normal limits and in 1 case of de Toni-Debre-Fanconi syndrome with slightly disturbed renal function, serum Mb level was high.2) Correlation coefficients of serum Mb with β2-M, BUN and Cr were 0.904, 0.777 and 0.859 respectively.3) Urine Mb level was high in some cases with steroid-resistant nephrotic syndrome or Fanconi syndrome, but in the other cases it was normal.It seemed that serum Mb was a good indicator to detect an early change of progressing renal glomerular damage and urine Mb level was useful to estimate the function of renal tubules.Measurement of Mb was easier than that of β2-M, so it is a useful marker to estimate the progression of renal diseases in childhood.
一般社団法人国立医療学会の論文