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The clinical findings and the chromosome abnormalities of acute leukemia according to FAB classification were evaluated. This study included 120 cases from Aug. 1965 to May 1982 and these cases were 108 cases of acute myeloid leukemia and 12 cases of lymphoblastic leukemia. The classification of the 108 cases with acute myeloid leukemia was as follows. M1:25 cases, M2:53 cases, M3:17 cases, M4:7 cases, M5:6 cases and M6:none. The male/female ratio was 1.4. The mean age wsa as follows. 39.4 years of age:M1, 42.6:M2, 34.1:M3, 45.6:M4, and 57.6:M5. There was a tendency to younger patients with M3 and older than 40 with most of M4, M5. Though there were no differences for RBC, hemoglobin among subgroups, in M 5, platelet was higher than others. The differences were not seen either for WBC, its leukemia cell ratio, and nucleated cell count in the bone marrow. Many cases in M 2, showed lower percentage of leukmia cell in the bone marrow. There was no differences for LDH and uric acid. Hepatomegaly was less common in both M3 and M5 than others, splenomegaly was not seen in M3, M4 and M5. Lymphadenopathy was seen in over 50% of both M4 and M5. Meningeal leukemia was seen in 36% of M1. Gum hypertrophy was highly seen in both M4 and M5, and skin infiltration was on M5. Chromosome abnormalities were observed in 43 out of 71 cases(60.6%) in which chromosome analysis was done. Abnormalities on each group were 13 out of 19 cases (68.4%) in M1, 18 out of 35 (51.4%) in M2, 11 out of 12 (91.7%) in M3, one out of 3 in M4 and none out of 2 in M5. The t (9;22) were found in 7 cases with M1 and one with M2, t (8;21) in 11 with M2, in which 4 cases were lack of sex chromosome, and t (15;17) were in 11 cases with M3. 50% survival time for each group were 9 months for M1, 6 months for M2, 1 month for M3, 6.3 months for M4, and 2 months for M5 respectively. Compaired to M1, when the complete remission (CR) was once established, M2 showed prolonged duration of CR. After the DCMP two step therapy was introduced in April 1977 the 50% survival time were 12 months for M2 and 9 months for M1.Among 12 cases of acute lymphoblastic leukemia, 5 cases were L1, 7 were L2 and no L3 was observed. Most of the L1 cases had higher rate in leukemia cell of the bone marrow, hepatomegaly, splenomegaly and lymphadenopathy than L2.There was no significant differences between L1 and L2 as to the surface markers and survival time.
- 一般社団法人 国立医療学会の論文
一般社団法人 国立医療学会 | 論文
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