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• Seven cases of gout following the administration of diuretics in congestive heart failure were reported. It is said that diuretics is uricosuric when given intravenously in large doses, but diuretics cause uric acid retention resulting in hyperuricemia when administered orally over a prolonged period.In all cases, gouty attack occurred during congestive heart failure, but did not occur after open heart surgery in spite of intravenous administration of large doses.In addition to these mechanisms of diuretics, we concluded that in congestive heart failure hyperuricemia occurred because of decreased renal uric acid clearance by low cardiac output and increased purine-base catabolism by peripheral circulatory failure.

• 一般社団法人 国立医療学会の論文

一般社団法人 国立医療学会 | 論文

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