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A 79-year-old female patient developed amnesia and night delirium at the onset of de-mentia, and the symptoms ran a course of wave-like aggravation. At the age of 86, this patient died and was autopsied. Her cerebral histopathological findings consisted of ad-vanced amyloid angiopathy in arterioles and small arteries of the cerebral leptomeninges and cerebral cortex and lymphocytic infiltration in the leptomeninges and their perivascular re-gions. The cerebral cortex was found to have mild senile changes, such as senile plaques and Alzheimer neurofibrillary changes, but had many small scars and necrotic foci. Path-ological studies led to a diagnosis of multiple small infarcts in the cerebral cortex super-vening on advanced amyloid angiopathy. It is of interest to note that dementia can be of cerebrovascular origin in very old patients, as seen in this case.
一般社団法人国立医療学会の論文