An Autopsy Case of Carcinoma of the Bile Duct Presumptively caused by Thorotrast Accumulation

概要

論文の詳細を見る
The patient was 48-years-old Japanese male with the chief complaint of physoconia. He was administered Thorotrast for splenography 25 years ago.On admission marked jaundice with abnormal liver function test and ascites were noted.Abdominal X-ray-examination revealed nodular, partially net like and metalic density in the liver and splenic region suggesting an accumulation of Thorotrast.In spite of symptomatic, supportive and diuretic therapy and repeated abdominal puncture, the patient showed down hill course and died on the 22nd hospital day.Autopsy findings are as follows:1) Marked jaundice.2) Accumulation of Thorotrast with round cell infiltration and fibrosis in the liver, spleen and abdominal lymph nodes.3) Spleen, almost necrotic.4) Carcinoma of the bile duct with liver cirrhosis and formation of a false bile duct in the peripheral lobural region.In the Glison's sheathes here were marked fibrosis and round cells infiltration.5) Adenocarcinoma with cancerous erosion in the cholecystic mucous membrane.6) Metastatic carcinpxna and fibrs in the peripancreatic and perigastric lymphatic tissue.7) Epitherial cyst in the Oesophagus.Onn radioactive count of the liver and spleen by Net Counter showed the peaks concur with TI208, Ac228 and Bi212.
一般社団法人国立医療学会の論文