Treatment of Muscular Dystrophy with Anabolic Steroid and Digitoxin
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Recently Dowben reported that the administration of anabolic steroid and digitoxin was effective for the treatment of progressive muscular dystrophy. Following his method we tried to treat the dystrophic patients to re-evaluate his idea.Eighteen patients (10 Duchnne, 6 limb-girdle and 2 facioscapulohumeral type) were given 4-hydroxy-17α-methyltestosterone (0.5-0.6 mg/kg/day) and digitoxin (0.01-4.012mg/kg/week in divided dosis). All the patients were examined by muscle testing and chronological serum creatine phosphokinase (CPK) determination. During treatment, the serum CPK revealed various changes, Only 2 of 18 patients (Duchenne and limb-girdle type) showed a remarkable decrease of serum CPK activities, with slight increase of muscle strength, however, a few months later CPK levels increased up to the pre-treatment level.Eighteen patients (17 Duchenne and 1 limb-girdle type) were divided into 2 groups, the former given 4-hydroxy-17α-methyltestosterone alone and the latter, in combination with digitoxin. CPK levels were measuredd every 2 weeks. During treatment CPK levels were unchanged or slightly decreased for a few weeks and then abruptly increased up to twice of pre-treatment levels. This rebound phenomenon was observed in both groups but the time of rebound in the latter group was delayed about 2 weeks in compared with the former.In the result, Dowben's treatment seems to be ineffective for muscular dystrophy, but the delayed rebound phenomenon of CPK in the latter group is very interesting from biochemical view point. The mechanism of the rebound phenomenon of the serum CPK is open to be clarified.
- 一般社団法人 国立医療学会の論文
一般社団法人 国立医療学会 | 論文
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