The Activities of Lactic Dehydrognase in Serum and Effusion of Malignant Tumors and Some Other Diseases
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概要
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A) It has been a focus of medical interest that the activity Of lactic dehydrogenase in serum (SLD) is of some value as an adjuvant tool in diagnosing malignancies.To asses the diagnostic value of this enzyme, SLD was determined in 470 cases with malignancies and other diseases.The method of Wróblewski and La Due with some slight modifications was used for the determination of SLD. in this study.1) In 263 cases with malignancies, the range of SLD levels was 157 and 9550. Though the elevation was of course not a sine qua non in malignancies, it is certain that there was a tendency to elevate SLD levels in malignancies, Marked elevations were found in hepatomas, leukemias and cases with widely spread metastasis in any kind of cancer, particularly with metastasis to the liver.2) In non-tumor diseases, three major categories were examined.a) In acute hepatitis or liver cirrhosis, elevations of medium ;range were commonly found, and when the course was favorable, the activity l lowered gradually.b) In myocardial infarction SLD was markedly elevated in their acute phasis, and when the injuries subsided uneventfully, the SLD level lowered, gradually. The speed of reduction, however, in much slower than that of S-GOTTc) In pulmonary tuberculosis or suppurative lesions in the lung, SLD levels within the normal range were found in the majority of the cases.B) The ratio of serous fluid to serum activity for lactic dehydrogenase (LD) was determined in 54 patients with effusions due to various diseases.In 56% of the 32 patients with malignant neoplasms had ratios of more than 1. 0.In 75% of the patients with inflammatory in nature, however, had too high ratios.The results of this study indicate that the activity in the effusion fluid of LD investigated does not clearly differentiate malignance from benign effusion.
- 一般社団法人 国立医療学会の論文
一般社団法人 国立医療学会 | 論文
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