Pseudohyphal growth induced by exposure of yeast cells to subinhibitory levels of antifungal azoles in Candida tropicalis.
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概要
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Summary: The azole class of compounds kills fungal cells through an inhibition of ergosterol biosynthesis resulting in malfunction and breakdown of cell membranes. Subinhibitory levels of these compounds were found bringing about a transition from yeast form to pseudohyphal one in Candida tropicalis, as well as ethanol reported previously. The other classes of inhibitors for ergosterol biosynthesis, terbinafine and amorolfin, also caused the transition. These findings implicated the function of ergosterol for filamentous growth. Although depolarized cell growth was observed to precede filamentation during the process of ethanol-induced pseudohyphal formation in this organism, no distinct depolarization was found to occur during the process induced by these antifungal compounds.
- 日本植物形態学会の論文
日本植物形態学会 | 論文
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