The Effect of Stellate Ganglion Block on Nitrogen Oxide Levels

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Nitric oxide (NO), which has been recognized as the endotherium-derived relaxing factor (EDRF), induces vascular relaxation, which leads to lowered vascular resistance. In this study we examined the effects of stellate ganglion block (SGB) on the circulating NO3- levels, as a measure of ongoing NO production in adults, and on the urine levels which integrate the total body production.The subjects of the study were eighteen healthy adults (21 hands). They received SGB at the C7 levels with 8ml of 1 per cent mepivacaine. NO3- was measured by HPLC. Heart rate, blood pressure, hematocrit, red blood cell count, white blood cell count, platelet count, and electrolytes were measured as hemodynamic variables before and after SGB.The plasma NO3- levels after SGB 34.5±18.2μmol/l in the affected side were significantly lower compared to the those before SGB 37.4±21.9μmol/l (p<0.05). Red blood cell, hematocrit, and platelet count decreased. Blood pressure and heart rate had no significant differences.Depressed NO3- levels in the plasma were observed after SGB, suggesting that SGB inhibits NO production in vivo.
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