A New Medical Treatment for Trigeminal Neuralgia with the Combination of Sho-saiko-to and Keishi-ka-syakuyaku-to

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Aim of investigation: The purpose of this study was to determine the efficacy of a Kampo formula consisted of Sho-saiko-to and Keishi-ka-syakuyaku-to to trigeminal neuralgia.Materials and methods: Extract preparations of Sho-saiko-to and Keishi-ka-syakuyaku-to were simultaneously prescribed to 13 patients with idiopathic trigeminal neuralgia for two weeks. Intensity of pain was measured with visual analogue scale. The degree of daily-activity restriction in terms of eating and washing the face was graded into four ranks. These parameters were measured before and two weeks after the commencement of the formula and analyzed with Wilcoxon's signed rank test. Frequency of paroxysms and severity of entire symptoms at the end of administration were expressed in numerical scores where initial status was represented as 10.Results: Intensity of subjective pain was significantly reduced (P=0.0030) after two-week administration of the Kampo formula. Restriction of eating and washing the face was also significantly improved (P=0.0158 and 0.0021 respectively). Frequency of paroxysms decreased from 10 to 2.8 (mean). Severity of entire symptoms also decreased to 3.6.Conclusion: The formula of Sho-saiko-to and Keishi-ka-syakuyaku-to was thought to be an effective option for the treatment of trigeminal neuralgia.
一般社団法人日本ペインクリニック学会の論文