Role of spinal thrombin and platelet-derived growth factor in the expression of chronic pain-like state in mice

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概要

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• Recently, our understanding of the role of serine proteases such as thrombin has been expanded to include actions in the nervous system. Thrombin affects protease-activated receptors (PARs), which are a family of G protein-coupled receptors. It is considered that PARs are implicated in responses to injury, notably in inflammation and repair. In particular, PAR-1, which is one of a PAR subtype and mediates most of the known proinflammatory actions of thrombin, is expressed by platelets, endothelial cells, neurons and astrocytes. Furthermore, it has been reported that PAR-1 is expressed in subsets of primary sensory neurons, suggesting that PAR-1 may be implicated in pain perception.It has been reported that thrombin induces the activation of platelets and promotes the expression or the release of platelet-derived growth factor (PDGF) from α-granule of platelets. Recent studies have demonstrated that PDGF and its receptor could be located in myelinated and unmyelinated primary sensory neurons and in the spinal cord. Thus, these findings support the idea that PDGF, which is mostly present in the blood vessels, may play an important role in the physiological responses including pain perception. Taken together, these findings raise the fascinating possibility that PDGF associated with PAR may be implicated in pain perception.This review attempts to summarize the role of the spinal thrombin/PAR-and PDGF/PDGF receptor-mediated signaling pathways in the development of chronic pain-like state in mice.

• 一般社団法人 日本ペインクリニック学会の論文

一般社団法人 日本ペインクリニック学会 | 論文

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