MEASUREMENT OF EXTENT OF INCREASED CAPILLARY PERMEABILITY

概要

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1) The colorimetric determination for extraction of trypan blue which was firmly bound to tissue protein, by the method of digesting with proteolytic enzymes or decomposing tissue protein with acid or alkali was unsuccessful.2) Using proteolytic digestion of the skin, Evans blue was extracted from the skin in good yield. In the range of 0.25×10-8 to 10×10-8M concentrations of Evans blue, the correlation between the amounts of injected and extracted dye was linear, and the average recovery of the dye from the rat skin was 92.5per cent.3) Capillary permeability varied with the injected areas of the dorsal skin.The amount of dye accumulated at the site of injury near the abdomen, head or tail were distinctly greater than in areas around the center of the back. Introductions of the venom around the center of the back gave a comparatively constant value and were used for the exact determination of an increased capillary permeability.
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