IMMUNOCHEMICAL STUDIES ON BACTERIAL BLOOD GROUP SUBSTANCES:I. ABSORPTION OF THE BLOOD GROUP SPECIFIC ANTIBODIES IN BACTERIAL ANTISERA BY SIMPLE SUGARS

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概要

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• 1. O(H) substance of bacteria. Anti-O(H) antibody in anti-S. Poona immune chicken serum was inhibited in its reaction by L-fucose. This indicates that blood group specific activity of O(H) substance in S. Poona, would be determined by L-fucose. However, anti-O(H) antibody in anti-Sh. dysenteriae immune chicken serum was principally inhibited by D-galactose and raffinose. Therefore, the O(H) substance in S. Poona and that in Sh. dysenteriae would be somewhat different in structure, and the former would be in higher stage of development.2. FA and A substances in bacteria. The reaction of anti-A antibody, which was obtained by immunizing rabbits with S. paratyphi B 8006, containing FA sub-stance, or with S. riogrande or E. freundii B90, both of which contain A substance, was inhibited strongly by N-acetyl-D-galactosamine, and weakly by N-acetyl-D-glucosamine. This indicates that FA and A subsances in bacteria and human beings similarly would have specific activities of their blood groups determined by N-acetylhexosamine, especially by N-acetylgalactosamine.3. B substance in bacteria. Anti-B antibody in anti-E. coli O86 immune chicken serum was principally inhibited in its reaction by D-galactose and raffinose. This indicates that B substance, both in bacteria and human beings, similarly would have its blood group specific activity determined by D-galactose.4. C(A+B) substance in bacteria. Specific activity of the C(A+B) substance found in A substance is determined by N-acetylgalactosamine. Specific activity of the C substance found in B substance can be determined by D-galactose. However, anti-B-containing anti-C agglutinin in anti-Sh. dysenteriae R form immune chicken serum was inhibited by both sugars. Therefore the C substance in this case would be found in a stage preceding the development into A and B substances.5. Somatic antigens 5 and 1 in bacteria. The specific activity of somatic antigen 5, which is related to FA substance, is determined by N-acetylgalactosamine. The specific activity of somatic antigen 1, which was reported by Iseki and Kashiwagi(17) to induce phage conversion, is determined by sugars containing glucose.

• 財団法人 学会誌刊行センターの論文

著者

• ISEKI Shoei

  Department of Legal Medicine, School of Medicine Gunma University

• FURUKAWA Ken

  Department of Legal Medicine, School of Medicine Gunma University

• SAEKI NAOMICHI

  Department of Legal Medicine, School of Medicine

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• サルモネラG,RおよびU群での血流型活性抗原の遺伝 (サルモネラのO抗原の遺伝的解析-1,2-〔英文〕)
• Studies on secretor specific H antigen of water-soluble blood group substances. I. Findings of anti-H(Se) precipitin in eel sera.:Findings of Anti-H(Se) Precipitin in Eel Sera
• Immunochemical studies on human cancer. I. Cancer-associated antigen reacting with anti-stomach cancer immune serum.:Cancer-Associated Antigen Reacting with Anti-Stomach Cancer Immune Serum
• Immunochemical Studies on Bacterial Blood Group Substances:VI. Structures of A-Active Oligosaccharides Isolated from Salmonella riogrande Lipopolysaccharide
• Immunochemical Studies on Bacterial Blood Group Substances:VII. Oligosaccharides from Shigella dysenteriae Lipopolysaccharide
• Immunochemical Studies on Bacterial Blood Group Substances. V:Structures of B determinant groups
• IMMUNOCHEMICAL STUDIES ON BACTERIAL BLOOD GROUP SUBSTANCES:I. ABSORPTION OF THE BLOOD GROUP SPECIFIC ANTIBODIES IN BACTERIAL ANTISERA BY SIMPLE SUGARS

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