Immunochemical studies on human cancer. I. Cancer-associated antigen reacting with anti-stomach cancer immune serum.:Cancer-Associated Antigen Reacting with Anti-Stomach Cancer Immune Serum
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概要
- 論文の詳細を見る
Rabbit antiserum immunized with water-soluble extract of stomach cancer and absorbed with normal human blood plasma and stomach mucosa extract contained a precipitin which reacted not only with the stomach cancer but also with colon cancer extracts. The precipitation reaction was inhibited by both D-glucosamine and D-galactosamine. The absorbed specific antiserum reacted with colon cancer extracts, but not with embryonic tissue extracts. These findings demonstrate an antigenic difference between carcinoembryonic antigen (CEA) and the antigen found in gastric cancers in this study.The antigenic material eluted after polyacrylamide gel electrophoresis showed a single protein band on disc-electrophoresis and no color developed with alcian blue or formazan staining for glycoprotein, indicating that the antigen found in gastric cancers in this study consists principally of protein. The antigenic substance in the cancer tissue may be excreted into the urine in cancer patients.
- 日本学士院の論文
著者
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Takizawa Hisao
Department Of Legal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical University
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FURUKAWA Ken
Department of Legal Medicine, School of Medicine, Gunma University
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ISEKI Shoei
Department of Legal Medicine, School of Medicine Gunma University
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FURUKAWA Ken
Department of Legal Medicine, School of Medicine Gunma University
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