Transition in the Character of Immunological Memory in Mice after Immunization:I. Memory for IgM and IgG Antibody Responses
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概要
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The immunological memory in antibody response of mice to bovine serum albumin was investigated at the level of IgM and IgG antibody-forming cells. The antigen at a dose much lower than required for eliciting a detectable level of the primary antibody response could latently activate the immune machinery to an extent adequate for specific recall, whereas higher doses of antigen were effective in evoking strong anamnestic response. The potentiality to develop the anamnestic response was found even in the latent phase of the primary antibody response and was maintained for more than 2 months. The immunological memory acquired in an early phase after the primary immunization mainly involved IgM antibody response and late memory concerned IgG response.
- 財団法人 学会誌刊行センターの論文
著者
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Kawaguchi Susumu
Department Of Neurosurgery Hirosaki University School Of Medicine
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KATSURA Yoshimoto
Department of Bacteriology and Serology, Chest Disease Research Institute, Kyoto University
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TAKAOKI Muneo
Biological Research Laboratories, Takeda Chemical Industry, Ltd.
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MURAMATSU Shigeru
Department of Zoology, Faculty of Science, Kyoto University
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