Evidence that low level of plasma progesterone in pubertal rats enhances prolactin secretion induced by NSD 1015 (DOPA decarboxylase inhibitor).

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The effect of progesterone on prolactin secretion induced by DOPA decarbo-xylase inhibitor (NSD 1015) was compared between pubertal and adult female rats. In pubertal rats pretreated with pregnant mare serum gonadotropin (5 I.U. PMSG) at 28 days of age and in adult rats showing 4-day estrous cycles, a Silastic tubing (10 cm, PP or 5cm, P) was implanted at the time of ovariectomy (ovx) performed between 07:00 and 08:00 h on the day of estrus. When NSD 1015 (100mg/100 g B.W.) was administered at 11:30 h 3 days after the operation, plasma prolactin (PRL) levels increased, reached a peak 30 min after administration and declined to the level of pre-treatment at 60 min in both adult and pubertal rats. In pubertal rats, the peak value 30 min after ad-ministration was in P group two times more than in ovx group. On the other hand, in adult rats, the peak value at 30 min after administration in PP group was about twice the values observed in ovx or P groups. Plasma progesterone concentration in PP groups was about twice the levels in P groups. Therefore the progesterone treatment enhanced the responsiveness to the NSD 1015 administration in the pubertal P group of rats, though, in adult rats, this effect was seen only in the PP group. These results indicate that the circulating progesterone augments the anti-dopaminergic effect of NSD 1015 on PRL secretion more effectively in pubertal rats.
日本繁殖生物学会の論文