Incidence of implantation in adult rats treated with gonadotropins and its improvement by exogenous prolactin.

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The present investigation was undertaken to examine the incidence of pregnan-cy and the number of implantation sites in adult rats treated with varying doses of gonad-otropins, and to explore the factor(s) causing a diminished incidence of implantation. Adult female rats were primed with 10-40 IU of PMSG at 1100-1300 h on the day of early diestrus. The half of PMSG-primed rats were further injected with the same doses of hCG 52-54 h after PMSG injection. These gonadotropin-treated rats were mated with males and examined for the number of implantation sites 8 days after mating (day 8). The incidence of pregnancy decreased, in a dose-dependent manner, from 95.0 to 17.5% in PMSG (10-40 IU)-primed rats and from 90.0 to 27.5% in PMSG-hCG-primed rats. The number of implantation sites in pregnant rats treated with 10 and 20 IU of either PMSG or combined PMSG and hCG was comparable to the value observed for the untreated control rats. However, the number of implantation sites per mating rat was significantly less in rats treated with 30 and 40 IU of either PMSG or combined PMSG and hCG than in control rats (<I>P</I>< 0.001). Administrations of prolactin (10 or 15 IU/day) from days 1 through 7 significantly increased both the incidence of pregnancy and the number of implantation sites in rats treated with 40 IU of combined PMSG and hCG (<I>P</I><0.05-0.001). Injection of prolactin (15 IU/day) were found to maintain serum progesterone at high levels (152.7-237.2 ng/ml) during days 2-8 of pregnancy. These results suggest that the diminished number of implantation sites in adult rats treated with large doses of gonadotropins may be at least partially due to an insufficient progesterone secretion from the corpora lutea.
日本繁殖生物学会の論文

Incidence of implantation in adult rats treated with gonadotropins and its improvement by exogenous prolactin.

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日本繁殖生物学会 | 論文

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