Effect of .BETA.-adrenoceptor agonist (clenbuterol) on time of parturition and spontaneous activity of uterus during parturition in rats.

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The purpose of this study was to examine the effect of β-adrenoceptor agonist, clenbuterol, on parturition time and uterine activity during parturition in rats.<BR>The rats were intramuscularly injected with 0.15 μg clenbuterol twice a day at the specified times from day 20 of pregnancy to the delivery, and the parturition time was investigated. Twenty two of 26 intact and saline-treated control rats (84.6%) delivered before 12:00 on day 22 of pregnancy. On the contrary, 10 of 14 rats (71.4%), treated at 08:30 and 11:30, and 9 of 14 rats (64.3%), treated at 18:00 and 21:00 delivered after 12:00 on day 22 of pregnancy. In another series of experiments, the rats were intramuscularly injected with clenbuterol (0.45-2.25 pg) during parturition and the change of uterine contraction was investigated. In 4 of 5 rats, the frequency and the amplitude of uterine con-traction decreased and the deliveries interrupted for 194-384 min. After the interruption, the uterine contraction recoveried and the deliveries resumed. The noenates were physiologically and morpho-logically normal.
日本繁殖生物学会の論文