Serum concentrations of free testosterone in beagle dogs.

概要

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Serum concentrations of free testosterone in beagle dogs were determined. Dextran-coated char-coal was used for separating testosterone-binding globulin (TBG)-bound steroid from the unbound fraction. Having a measure of TBG levels together with a knowledge of the total endogenous testo-sterone permitted the estimation of free testosterone based on the binding affinities of serum proteins. The concentrations of free testosterone (pg/ml, mean±Em) in mature males (391±37) were signi-ficantly higher (P<0.001) than those in mature females (47±16). No annual variations of free testo-sterone concentrations were observed in mature male dogs. Serum concentrations of free testosterone were low (<100 pg/ml) at 3 months of age, increased with days of age and appeared constantly from 1 year of age through 10 years in male dogs.
日本繁殖生物学会の論文