Experimental studies on antigonadotrophin formation followed on repeat injection with gonadotrophin:II. Experimental studies on mice

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Antigonadotrophin formation was produced by the repeated injection of 5 i. u. per days with pregnant mare's serum gonadotrophin and chorionic gonadotrophin into immature female mice.<BR>These antigonadotrophin were recognized after thirty days in the tests of P. M. S. G. injection groups, and after sixty days in the C. G. injection groups.<BR>This antigonadotrophic activity seems to be augmentative as these substances were injected continuously.<BR>Upon the ninety days examination, it was unchanged upon the ovarian weights between injected groups and controls.<BR>It is hard to explain how antigonadotrophin formation cause the increasing of basophiles percentages in hypophysis, however, upon this experiment the increases of these cell were demonstrable in the most cases.
日本繁殖生物学会の論文